| Annotated protein: | Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61). Gene symbol: ITGB3. Taxonomy: Mus musculus (Mouse). Uniprot ID: O54890 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ITGB3 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of synaptic membrane (GO:0099699) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Shi Y, et al. "Integrins control dendritic spine plasticity in hippocampal neurons through NMDA receptor and Ca2+/calmodulin-dependent protein kinase II-mediated actin reorganization" J Neurosci. 2006 Feb 8;26(6):1813-22 PMID:16467530 |
| Figure(s): | fig 1A-1G |
| Annotation description: | ITGB3 was localized in synapses of hippocampal neurons. ITGB3 was enriched in synaptic membrane fractions. 16/01/2018 Pim - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Western blot Biochemical fractionation (generic) |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2210 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |