Annotated protein:Leucine-rich repeat-containing protein 4 (Brain tumor-associated protein MBAG1) (Netrin-G2 ligand) (NGL-2). Gene symbol: LRRC4. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q99PH1
antibody wiki:
SynGO gene info:SynGO data @ LRRC4
Ontology domain:Cellular Component
SynGO term:integral component of postsynaptic density membrane (GO:0099061)
Synapse type(s):hippocampus
Schaffer collateral synapse (CA3->CA1)
Annotated paper:Matsukawa H, et al. "Netrin-G/NGL complexes encode functional synaptic diversification" J Neurosci. 2014 Nov 19;34(47):15779-92 PMID:25411505
Figure(s):fig 1E
Annotation description:Immunoparticles for LRRC4 were mostly detected postsynaptically in the vicinity of the postsynaptic density of dendritic spines in SR.

2/1/2018 Pim
- LRRC4 is referred to as NGL2 in this paper.
- Literal: "Immunoparticles for NGL1 and NGL2 were mostly detected postsynaptically in the vicinity of the postsynaptic density of dendritic spines in SLM and SR, respectively." Note: 'SR' means 'CA1 stratum radiatum'
- Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen.
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Electron Microscopy
Annotator(s):Hwajin Jung (ORCID:0000-0001-6194-9648)
Eunjoon Kim (ORCID:0000-0001-5518-6584)
Lab:Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea
SynGO annotation ID:2219
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology