| Annotated protein: | Potassium voltage-gated channel subfamily D member 2 (RK5) (Shal1) (Voltage-gated potassium channel subunit Kv4.2). Gene symbol: KCND2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q63881 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ KCND2 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic membrane (GO:0099055) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Kim J, et al. "Regulation of dendritic excitability by activity-dependent trafficking of the A-type K+ channel subunit Kv4.2 in hippocampal neurons" Neuron. 2007 Jun 21;54(6):933-47 PMID:17582333 |
| Figure(s): | Fig.S1 |
| Annotation description: | Fig.S1: "Immunogold labeling for endogenous Kv4.2 showing its expression in CA1 spines. ... Most gold particles were detected in postsynaptic spines but not directly in the postsynaptic density." - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2239 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |