| Annotated protein: | Gamma-aminobutyric acid receptor subunit gamma-2 (GABA(A) receptor subunit gamma-2). Gene symbol: GABRG2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P18508 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GABRG2 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic specialization membrane (GO:0099060) |
| Synapse type(s): | hippocampus, GABAergic cerebellum, GABAergic globus pallidus, GABAergic |
| Annotated paper: | Somogyi P, et al. "The gamma 2 subunit of the GABAA receptor is concentrated in synaptic junctions containing the alpha 1 and beta 2/3 subunits in hippocampus, cerebellum and globus pallidus" Neuropharmacology. 1996;35(9-10):1425-44 PMID:9014159 |
| Figure(s): | Fig.5-11 |
| Annotation description: | Title: "The gamma 2 subunit of the GABAA receptor is concentrated in synaptic junctions containing the alpha 1 and beta 2/3 subunits in hippocampus, cerebellum and globus pallidus." - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2257 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |