| Annotated protein: | Filamin-A-interacting protein 1 (FILIP). Gene symbol: FILIP1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9CS72 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ FILIP1 |
| Ontology domain: | Biological Process |
| SynGO term: | modification of postsynaptic structure (GO:0099010) |
| Synapse type(s): | cerebral cortex, glutamatergic |
| Annotated paper: | Yagi H, et al. "Filamin A-interacting protein (FILIP) is a region-specific modulator of myosin 2b and controls spine morphology and NMDA receptor accumulation" Sci Rep. 2014 Sep 15;4:6353 PMID:25220605 |
| Figure(s): | Figures 2, 3, 7 |
| Annotation description: | This paper shows that FILIP deletion leads to a shorter spine length in the piriform cortex and that exogenous FILIP results in an elongated spine length in hippocampal neurons. 23/3/2017 Pim - The effect of FILIP1 on spine morphology has effects on synaptic transmission as shown in Fig.8 |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Harold MacGillavry (ORCID:0000-0002-6153-3586) Casper Hoogenraad (ORCID:0000-0002-2666-0758) |
| Lab: | Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands |
| SynGO annotation ID: | 226 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |