| Annotated protein: | Cell adhesion molecule 1 (Immunoglobulin superfamily member 4) (IgSF4) (Nectin-like protein 2) (NECL-2) (Spermatogenic immunoglobulin superfamily) (SgIgSF) (Synaptic cell adhesion molecule) (SynCAM) (Tumor suppressor in lung cancer 1) (TSLC-1). Gene symbol: CADM1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8R5M8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CADM1 |
| Ontology domain: | Biological Process |
| SynGO term: | maintenance of postsynaptic specialization structure (GO:0098880) |
| Synapse type(s): | hippocampus Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Robbins EM, et al. "SynCAM 1 adhesion dynamically regulates synapse number and impacts plasticity and learning" Neuron. 2010 Dec 9;68(5):894-906 PMID:21145003 |
| Figure(s): | Fig. 5 |
| Annotation description: | This study used a transgenic mouse model to test roles of SynCAM 1 in synapse maintenance. Figs. 2A,B and 2F,G show that the overexpression of SynCAM 1 in excitatory neurons is sufficient to increase the number of excitatory synapses and of dendritic spines, a morphological correlate of excitatory synapses. The results in Fig. 5E demonstrate that this increase is lost when SynCAM 1 overexpression is turned off. The mEPSC recordings in Fig. 5C,D support a loss of functional excitatory synapses when SynCAM 1 overexpression is shut down. These results support an instructive role of SynCAM 1 first in the induction and then the maintenance of excitatory synapse, including postsynaptic sites. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal Electrophysiology (generic) |
| Annotator(s): | Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863) |
| Lab: | Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA |
| SynGO annotation ID: | 230 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |