| Annotated protein: | Cell adhesion molecule 1 (Immunoglobulin superfamily member 4) (IgSF4) (Nectin-like protein 2) (NECL-2) (Spermatogenic immunoglobulin superfamily) (SgIgSF) (Synaptic cell adhesion molecule) (SynCAM) (Tumor suppressor in lung cancer 1) (TSLC-1). Gene symbol: CADM1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8R5M8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CADM1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic membrane (GO:0099055) |
| Synapse type(s): | hippocampus Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Perez de Arce K, et al. "Topographic Mapping of the Synaptic Cleft into Adhesive Nanodomains" Neuron. 2015 Dec 16;88(6):1165-1172 PMID:26687224 |
| Figure(s): | Fig 2, Fig 3 |
| Annotation description: | SynCAM 1 marks the edge of the synaptic cleft and approximately 70% of the SynCAM 1 protein that is in synaptic membranes is present in the postsynaptic membrane. A smaller fraction of the protein is presynaptically localized. 6/3/2017 Pim - localization of SynCAM1 in the postsynaptic membrane can be inferred from its TM domain. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Super resolution |
| Annotator(s): | Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863) |
| Lab: | Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA |
| SynGO annotation ID: | 231 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |