| Annotated protein: | CASK protein (Calcium/calmodulin dependent serine protein kinase). Gene symbol: CASK. Taxonomy: Bos taurus (Bovine). Uniprot ID: A5D7B9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CASK |
| Ontology domain: | Cellular Component |
| SynGO term: | presynapse (GO:0098793) |
| Synapse type(s): | retina |
| Annotated paper: | Anjum R, et al. "Differential synaptic distribution of the scaffold proteins Cask and Caskin1 in the bovine retina" Mol Cell Neurosci. 2014 Sep;62:19-29 PMID:25123431 |
| Figure(s): | Fig. 5 |
| Annotation description: | Fig.4 shows that Cask is localized in close vicinity to the active zone protein RIM1/2 in ribbon and conventional synapses. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863) |
| Lab: | Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA |
| Additional literature: | Using cortex from adult male rats, this study shows that CASK is enriched in a presynaptic cytomatrix preparation. The authors applied a synaptosome subfractionation protocol that is based on pH-dependent differential detergent solubility. Fig.7C shows the immunoblot for CASK and Table 1 the molecular components found in this fraction. @ PMID:11604139 |
| SynGO annotation ID: | 232 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |