| Annotated protein: | Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor). Gene symbol: ADRB2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P10608 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ADRB2 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic membrane (GO:0099055) |
| Synapse type(s): | hippocampus Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Davare MA, et al. "A beta2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2" Science. 2001 Jul 6;293(5527):98-101 PMID:11441182 |
| Figure(s): | Fig. 1a, 3 |
| Annotation description: | Beta2 Adrenergic receptor immunoprecipitates together with the L-type calcium channel Cav1.2 (Fig. 1a). Immunolabelling of rat hippocampal sections indicates co-localization with Cav1.2 at synapses using an antibody directed against the Beta2 Adrenergic receptor (Santa Cruz Biotechnology, H-20) (Fig.3). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal IP + WB/MSMS |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| SynGO annotation ID: | 2351 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |