| Annotated protein: | Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2). Gene symbol: TAOK2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9JLS3-2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ TAOK2 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synaptic membrane adhesion (GO:0099179) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Yasuda S, et al. "Activity-induced protocadherin arcadlin regulates dendritic spine number by triggering N-cadherin endocytosis via TAO2beta and p38 MAP kinases" Neuron. 2007 Nov 8;56(3):456-71 PMID:17988630 |
| Figure(s): | Fig.5, 6, 7 |
| Annotation description: | Fig.5: "Homophilic Interaction of Arcadlin Causes Internalization via the Activation of Arcadlin-TAO2β-p38 MAPK Signaling Pathway" Fig.6: "Feed-Back Phosphorylation of TAO2β at Ser1038 by p38 MAPK Is Essential for the Endocytosis of Arcadlin" Fig.7: "The Arcadlin-TAO2β-p38 MAPK Pathway Mediates the Internalization of N-Cadherin" TAO2 beta-isoform protein binds to Arcadlin and is needed for the endocytosis of the Arcadlin protein. The Arcadlin protein regulates synapse adhesion via endocytosis of N-cadherin (see Fig.2+3+7). |
| Evidence tracking, Biological System: | Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Western blot |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2369 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |