| Annotated protein: | Neuronal membrane glycoprotein M6-a (M6a). Gene symbol: GPM6A. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q812E9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GPM6A |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synapse organization (GO:0050807) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Formoso K, et al. "Evidence for a role of glycoprotein M6a in dendritic spine formation and synaptogenesis" Mol Cell Neurosci. 2016 Dec;77:95-104 PMID:27793698 |
| Figure(s): | Fig. 4,5 |
| Annotation description: | Overexpression of M6a increases number of synapses in primary hippocampal cultures (Fig. 4). Two single nucleotide polymorphisms (F93C and I97S) impair this function (Fig.5). |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 2381 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |