| Annotated protein: | Glypican 4. Gene symbol: GPC4. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q642B0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GPC4 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of presynapse assembly (GO:1905606) |
| Synapse type(s): | hippocampus |
| Annotated paper: | de Wit J, et al. "Unbiased discovery of glypican as a receptor for LRRTM4 in regulating excitatory synapse development" Neuron. 2013 Aug 21;79(4):696-711 PMID:23911103 |
| Figure(s): | fig 6 |
| Annotation description: | GPC4-Fc reduces LRRTM4 induced presynaptic differentiation in coculture assays. GPC4 knockdown decreases synapse formation onto LRRTM4-expressing HEK cells in coculture assays. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2394 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |