| Annotated protein: | Netrin-G1 (Laminet-1). Gene symbol: NTNG1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8R4G0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NTNG1 |
| Ontology domain: | Biological Process |
| SynGO term: | modulation of chemical synaptic transmission (GO:0050804) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Matsukawa H, et al. "Netrin-G/NGL complexes encode functional synaptic diversification" J Neurosci. 2014 Nov 19;34(47):15779-92 PMID:25411505 |
| Figure(s): | fig 3, 4, 5 |
| Annotation description: | Post-tetanic potentiation (PTP) at the TA-CA1 synapses was impaired in netrin-G1-KO. fEPSP potentiation by PDBu (a PKC activator; 0.4 μm) was reduced at TA-CA1 synapses in netrin-G1-KO. LTP induced by TBuS (an LTP-stimulation protocol) at the TA-CA1 synapses was attenuated in netrin-G1-KO. Synaptic potentiation following consecutive four TBuS trains was decreased in netrin-G1-KO. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Field recordings |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2404 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |