| Annotated protein: | Netrin-G2 (Laminet-2). Gene symbol: NTNG2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8R4F1 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NTNG2 |
| Ontology domain: | Biological Process |
| SynGO term: | modulation of chemical synaptic transmission (GO:0050804) |
| Synapse type(s): | hippocampus, glutamatergic Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Matsukawa H, et al. "Netrin-G/NGL complexes encode functional synaptic diversification" J Neurosci. 2014 Nov 19;34(47):15779-92 PMID:25411505 |
| Figure(s): | fig 2, 3, 4 |
| Annotation description: | Basal synaptic transmission was significantly reduced at MPP-DG synapses of netrin-G2-KO mice. MPP-DG synapses of netrin-G2-KO mice showed significantly increased PPR at all interstimulus intervals. PTP at the SC-CA1 synapses was facilitated in netrin-G2-KO. LTP induced by TBuS (an LTP-stimulation protocol) at SC-CA1 synapses was increased in netrin-G2-KO mice. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Field recordings |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2405 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |