| Annotated protein: | Receptor-type tyrosine-protein phosphatase O (R-PTP-O) (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTP-U2) (PTPase U2). Gene symbol: PTPRO. Taxonomy: Mus musculus (Mouse). Uniprot ID: E9Q612 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PTPRO |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synapse organization (GO:0050807) |
| Synapse type(s): | hippocampus, glutamatergic hippocampus, GABAergic |
| Annotated paper: | Jiang W, et al. "Identification of Protein Tyrosine Phosphatase Receptor Type O (PTPRO) as a Synaptic Adhesion Molecule that Promotes Synapse Formation" J Neurosci. 2017 Oct 11;37(41):9828-9843 PMID:28871037 |
| Figure(s): | fig 4, 5 |
| Annotation description: | Overexpression of PTPRO increases the synapse density in cultured hippocampal neurons. KD of PTPRO by shRNA decreases the glutamatergic and GABAergic synaptic strength. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2408 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |