| Annotated protein: | protein-tyrosine-phosphatase (EC 3.1.3.48). Gene symbol: PTPRT. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: F1LXJ9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PTPRT |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synapse organization (GO:0050807) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Lim SH, et al. "Synapse formation regulated by protein tyrosine phosphatase receptor T through interaction with cell adhesion molecules and Fyn" EMBO J. 2009 Nov 18;28(22):3564-78 PMID:19816407 |
| Figure(s): | fig 2, 3 |
| Annotation description: | Enhanced synapse formation by overexpression of PTPRT. Loss of synapses by knockdown of PTPRT. Knockdown of PTPRT in cultured neurons (DIV 13-16) decreased the frequency, but not amplitude of mEPSCs. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2409 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |