| Annotated protein: | non-specific serine/threonine protein kinase (EC 2.7.11.1). Gene symbol: PAK. Taxonomy: Drosophila melanogaster (Fruit fly). Uniprot ID: B7Z0W0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PAK1 SynGO data @ PAK2 SynGO data @ PAK3 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of neurotransmitter receptor localization to postsynaptic specialization membrane (GO:0098696) |
| Synapse type(s): | Neuro-muscular junction |
| Annotated paper: | Albin SD, et al. "Coordinating structural and functional synapse development: postsynaptic p21-activated kinase independently specifies glutamate receptor abundance and postsynaptic morphology" J Neurosci. 2004 Aug 4;24(31):6871-9 PMID:15295021 |
| Figure(s): | Figure 8 |
| Annotation description: | Fig.8: "Synaptic localization of Dlg is decreased in dock and Pak mutants" Abstract: "Here, we demonstrate that Pak signaling diverges into two independent, genetically separable signaling pathways that are capable of coordinating glutamate receptor abundance with the formation of SSR at the Drosophila NMJ. One pathway regulates glutamate receptor abundance. Within this pathway, Pak activity is specified by a required interaction with the adaptor protein Dreadlocks (Dock; Nck homolog), which we demonstrate is a synaptic protein at the Drosophila NMJ. A second Pak-signaling pathway controls the synaptic abundance of Dlg and the elaboration of SSR. Pak activity within this signaling pathway is independent of Dock function and requires an intact kinase domain." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Wide-field fluorescence |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| SynGO annotation ID: | 2433 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |