| Annotated protein: | Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP). Gene symbol: WASL. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: O08816 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ WASL |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Wegner AM, et al. "N-wasp and the arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapses" J Biol Chem. 2008 Jun 6;283(23):15912-20 PMID:18430734 |
| Figure(s): | Fig.1 |
| Annotation description: | Fig.1: "N-WASP localizes to spines and functional, excitatory synapses in hippocampal neurons" - Literal: "As shown in the higher magnification images, N-WASP puncta were in close apposition to the presynaptic marker SV2, suggesting it was in postsynaptic terminals (Fig. 1A). Consistent with this, N-WASP puncta almost completely merged with the postsynaptic marker PSD-95 (Fig. 1A), indicating that N-WASP localizes to the postsynaptic side of excitatory synapses." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Wide-field fluorescence |
| Annotator(s): | Ryan J. Farrell (ORCID:0000-0003-4022-8707) Ghazaleh Ashrafi (ORCID:0000-0001-7480-0826) Camila Pulido (ORCID:0000-0002-5648-066X) Jaime de Juan-Sanz (ORCID:0000-0002-1212-5623) Timothy Ryan (ORCID:0000-0003-2533-9548) |
| Lab: | Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA |
| SynGO annotation ID: | 2437 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |