| Annotated protein: | Voltage-dependent R-type calcium channel subunit alpha-1E (BII) (Brain calcium channel II) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (RBE-II) (RBE2) (Voltage-gated calcium channel subunit alpha Cav2.3). Gene symbol: CACNA1E. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q07652 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CACNA1E |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synaptic vesicle exocytosis (GO:2000300) |
| Synapse type(s): | thalamus, GABAergic |
| Annotated paper: | Joksovic PM, et al. "Isoflurane-sensitive presynaptic R-type calcium channels contribute to inhibitory synaptic transmission in the rat thalamus" J Neurosci. 2009 Feb 4;29(5):1434-45 PMID:19193890 |
| Figure(s): | Fig6A,B |
| Annotation description: | Use of a well-documented specific blocker of this type of voltage gated calcium channel reduces evoked inhibitory postsynaptic currents and increased paired pulse ratios, implying a presynaptic origin. 8/2/2018 Pim - The effect on Ca2+ is not shown directly in these experiments. However, CACNA1E is a known VGCC. The presynaptic action of CACNA1E inhibitor on ca2+-dependent SV release implies that CACNA1E is involved in 'voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (GO:0099626)'. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Ryan J. Farrell (ORCID:0000-0003-4022-8707) Ghazaleh Ashrafi (ORCID:0000-0001-7480-0826) Camila Pulido (ORCID:0000-0002-5648-066X) Jaime de Juan-Sanz (ORCID:0000-0002-1212-5623) Timothy Ryan (ORCID:0000-0003-2533-9548) |
| Lab: | Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA |
| SynGO annotation ID: | 2443 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |