| Annotated protein: | Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR). Gene symbol: PTPRF. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q64604 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PTPRF |
| Ontology domain: | Biological Process |
| SynGO term: | synapse adhesion between pre- and post-synapse (GO:0099560) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Kwon SK, et al. "Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation" J Biol Chem. 2010 Apr 30;285(18):13966-78 PMID:20139422 |
| Figure(s): | fig 1, 3, 5, 6 |
| Annotation description: | The first two FNIII domains of PTPRF are sufficient for NGL-3 binding. The first two FNIII domains of PTPRF are sufficient to induce postsynaptic PSD-95 clustering. 19/2/2018 Pim - PTPRF may be present at both at pre and postsynaptic locations (see feedback section). It is shown to mediate cell-cell adhesion with NGL-3 in a cell-adhesion assay (Fig.1+3+5). PTPRF is able to induce postsynaptic differentiation (Fig.6). |
| Evidence tracking, Biological System: | Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| Additional literature: | Trans-synaptic adhesion between NGL-3 and LAR regulates the formation of excitatory synapses. @ PMID:19252495 |
| SynGO annotation ID: | 2463 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |