Annotated protein:Voltage-dependent calcium channel gamma-5 subunit (Neuronal voltage-gated calcium channel gamma-5 subunit) (Transmembrane AMPAR regulatory protein gamma-5) (TARP gamma-5). Gene symbol: CACNG5. Taxonomy: Homo sapiens (Human). Uniprot ID: Q9UF02
antibody wiki:
SynGO gene info:SynGO data @ CACNG5
Ontology domain:Biological Process
SynGO term:regulation of postsynaptic neurotransmitter receptor activity (GO:0098962)
Synapse type(s):olfactory bulb, glutamatergic
Annotated paper:Kato AS, et al. "AMPA receptor subunit-specific regulation by a distinct family of type II TARPs" Neuron. 2008 Sep 25;59(6):986-96 PMID:18817736
Figure(s):Figure 1-6, 7, 8
Annotation description:TARP γ-5 is an integral membrane protein belonging to the type II family of TARPs.

Fig.1: TARP γ-5 is shown to interact with AMPARs
Fig.2: "γ-5 Modulates GluR2 but Not GluR1 Homomeric AMPA Receptors" (HEK cells)
Fig.3: "Subunit-Specific Modulation of GluR Homomers by Type II TARPs" (HEK cells)
Fig.4: "γ-5 Accelerates Deactivation and Both Accelerates and Enhances the Extent of Desensitization of GluR2iR-Containing AMPA Receptors" (HEK cells+ correlation of expression level and native AMPAR properties)
Fig.5: "γ-5 Lowers the Affinity of Glutamate on GluR2R-Containing AMPA Receptors" (HEK cells+ correlation of expression level and native AMPAR properties)
Fig.7: "γ-5 Preferentially Regulates AMPA Receptor Heteromers Composed of GluR2/3 Subunits" (HEK cells)
Fig.8: "Transfection of γ-5 into Neuronal AMPA Receptors Modifies Their Gating Properties" (dissociated cerebral cortex neurons)
Evidence tracking, Biological System:Intact tissue
Cultured neurons
Non-neuronal tissue
Evidence tracking, Protein Targeting:Over-expression
Evidence tracking, Experiment Assay:Electrophysiology (generic)
IP + WB/MSMS
Annotator(s):Hana Goldschmidt (ORCID:0000-0002-5676-366X)
Richard Huganir (ORCID:0000-0001-9783-5183)
Lab:Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA and Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21205, USA
SynGO annotation ID:2470
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology