| Annotated protein: | Glutamate receptor 2 (GluR-2) (AMPA-selective glutamate receptor 2) (GluR-B) (GluR-K2) (Glutamate receptor ionotropic, AMPA 2) (GluA2). Gene symbol: GRIA2. Taxonomy: Mus musculus (Mouse). Uniprot ID: P23819 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRIA2 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Jensen V, et al. "A juvenile form of postsynaptic hippocampal long-term potentiation in mice deficient for the AMPA receptor subunit GluR-A" J Physiol. 2003 Dec 15;553(Pt 3):843-56 PMID:14555717 |
| Figure(s): | Fig.6, Table 2 |
| Annotation description: | Fig.6: "Accumulation of the GluR-B subunits in somata and at synapses of GluR-A-deficient mice" - "...the number of anti-GluR-B labelled postsynaptic densities (PSDs) was about 1.5-fold increased compared to wild-type (Table 2)." - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2481 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |