| Annotated protein: | D(1A) dopamine receptor (Dopamine D1 receptor). Gene symbol: DRD1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q61616 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DRD1 |
| Ontology domain: | Biological Process |
| SynGO term: | modification of postsynaptic structure (GO:0099010) |
| Synapse type(s): | striatum, glutamatergic |
| Annotated paper: | Yagishita S, et al. "A critical time window for dopamine actions on the structural plasticity of dendritic spines" Science. 2014 Sep 26;345(6204):1616-20 PMID:25258080 |
| Figure(s): | Fig.1, 2 |
| Annotation description: | background: in glutamatergic synapses of medium spiny neurons that express the DRD1 (DR1-MSN) dopamine application within a critical period after synaptic stimulation is able to induce spine morphology changes. The effect is shown to be DRD1 dependent in two ways: 1. The authors state that the MSN neurons mainly express the DRD1 receptor 2. The effect on spine morphology is shown to be mediated by D1 and not the D2 receptor using pharmacological tools (SCH23390, a claimed selective D1 antagonist). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Two-photon microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2506 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |