Annotated protein:D(2) dopamine receptor (Dopamine D2 receptor). Gene symbol: DRD2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P61169
antibody wiki:
SynGO gene info:SynGO data @ DRD2
Ontology domain:Cellular Component
SynGO term:integral component of presynaptic membrane (GO:0099056)
Synapse type(s):amygdala, glutamatergic
amygdala, GABAergic
Annotated paper:Pinto A, et al. "Ultrastructural analysis of prefrontal cortical inputs to the rat amygdala: spatial relationships to presumed dopamine axons and D1 and D2 receptors" Brain Struct Funct. 2008 Sep;213(1-2):159-75 PMID:18340460
Figure(s):Fig.6
Annotation description:Fig.6: "Electron micrographs showing immunoperoxidase labeling for the D2 receptor within dendrites (D2-d in panel a and c), spines (D2-s in panel b), and axon terminals (D2-t in panels d and e) within the ICMs (panels a and d) and BLA (panels b, c, and e) of the AMG"
- "The D2R was frequently observed within dendrites (Fig. 6a, c) and spines (Fig. 6b)."
- "The D2R was frequently found within axonal profiles (Fig. 6d, e). Some of these formed either symmetric or asymmetric synapses (Fig. 6e) onto spines or distal dendrites."

- Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen.
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Electron Microscopy
Annotator(s):Pim van Nierop (ORCID:0000-0003-0593-3443)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:2509
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology