| Annotated protein: | D(1A) dopamine receptor (Dopamine D1 receptor). Gene symbol: DRD1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P18901 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DRD1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic membrane (GO:0099056) |
| Synapse type(s): | amygdala |
| Annotated paper: | Pinto A, et al. "Ultrastructural analysis of prefrontal cortical inputs to the rat amygdala: spatial relationships to presumed dopamine axons and D1 and D2 receptors" Brain Struct Funct. 2008 Sep;213(1-2):159-75 PMID:18340460 |
| Figure(s): | Fig.5 |
| Annotation description: | Fig.5: "Electron micrographs showing immunoperoxidase labeling for the D1 receptor within the ICMs" - "The D1R was most commonly found within spines (Fig. 5a, b) that typically received asymmetric synaptic inputs from unlabeled terminals. In some instances, D1R-labeled spines were seen to emerge from parent dendrites that were devoid of D1R labeling (Fig. 5c). The D1R was less commonly present within dendrites (Fig. 5d) or axon terminals (Fig. 5e)." - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2510 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |