Annotated protein:D(2) dopamine receptor (Dopamine D2 receptor). Gene symbol: DRD2. Taxonomy: Mus musculus (Mouse). Uniprot ID: P61168
antibody wiki:
SynGO gene info:SynGO data @ DRD2
Ontology domain:Cellular Component
SynGO term:integral component of presynaptic membrane (GO:0099056)
Synapse type(s):striatum, GABAergic
Annotated paper:Uchigashima M, et al. "Dopamine synapse is a neuroligin-2-mediated contact between dopaminergic presynaptic and GABAergic postsynaptic structures" Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):4206-11 PMID:27035941
Figure(s):Fig.2
Annotation description:Fig.2: "Expression profiles of dopamine receptors in the striatum"
- "In MSNs, the density of cell membrane-attached metal particles for D1R and D2R was comparably high in the soma, dendritic shaft, and dendritic spines (Fig. 2 A-C). In the neuropil, weak immunolabeling for D1R and D2R was also observed in terminals forming symmetric-but not asymmetric-synapses (Fig. 2C)."

- Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen.
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Electron Microscopy
Annotator(s):Pim van Nierop (ORCID:0000-0003-0593-3443)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:2514
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology