| Annotated protein: | D(2) dopamine receptor (Dopamine D2 receptor). Gene symbol: DRD2. Taxonomy: Mus musculus (Mouse). Uniprot ID: P61168 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DRD2 |
| Ontology domain: | Biological Process |
| SynGO term: | presynaptic modulation of chemical synaptic transmission (GO:0099171) |
| Synapse type(s): | striatum |
| Annotated paper: | Wang W, et al. "Regulation of prefrontal excitatory neurotransmission by dopamine in the nucleus accumbens core" J Physiol. 2012 Aug 15;590(16):3743-69 PMID:22586226 |
| Figure(s): | Fig.1, 3, 8, 9 |
| Annotation description: | Fig.1: "Amphetamine and endocannabinoids produce frequency-dependent filtering at corticoaccumbal terminals" Fig.3: "D2Rs produce corticoaccumbal inhibition through endocannabinoids" - "Presynaptic inhibition through endocannabinoids is dependent on D2 and group 1 metabotropic glutamate receptors (mGluRs)" Fig.8: "Presynaptic excitation of D2R-expressing MSNs by D2Rs is prevented by endocannabinoids" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp Optical physiology |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2520 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |