| Annotated protein: | 14-3-3 protein gamma [Cleaved into: 14-3-3 protein gamma, N-terminally processed]. Gene symbol: YWHAG. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P61983 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ YWHAG |
| Ontology domain: | Cellular Component |
| SynGO term: | presynapse (GO:0098793) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Li Y, et al. "Modulation of inactivation properties of CaV2.2 channels by 14-3-3 proteins" Neuron. 2006 Sep 21;51(6):755-71 PMID:16982421 |
| Figure(s): | fig 1b |
| Annotation description: | From results section: To identify the potential subcellular site of interaction between 14-3-3 and CaV2.2 channels, we coimmunostained cultured rat hippocampal neurons with either the 14-3-3γ or α1B antibody, together with the synapsin I antibody that specifically labels the presynaptic terminals (Sudhof and Jahn, 1991). Although both 14-3-3γ and α1B subunits distribute broadly in both the somata and neurites, they exhibit extensive costaining with synapsin I in presynaptic terminals (Figure 1B), suggesting that this protein complex may be present in presynaptic terminals and play a role in regulating synaptic transmissions. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Rita Reig-Viader (ORCID:0000-0002-6893-6177) Àlex Bayés (ORCID:0000-0002-5265-6306) |
| Lab: | Molecular Physiology of the Synapse Laboratory, Biomedical Research Institute Sant Pau, 08025 Barcelona, Spain and and Universitat Autnoma de Cerdanyola del Valls, Spain Barcelona, 08193 Bellaterra |
| SynGO annotation ID: | 2533 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |