| Annotated protein: | D(2) dopamine receptor (Dopamine D2 receptor). Gene symbol: DRD2. Taxonomy: Mus musculus (Mouse). Uniprot ID: P61168 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DRD2 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of neurotransmitter uptake (GO:0051580) |
| Synapse type(s): | striatum, dopaminergic |
| Annotated paper: | Schmitz Y, et al. "Altered dopamine release and uptake kinetics in mice lacking D2 receptors" J Neurosci. 2002 Sep 15;22(18):8002-9 PMID:12223553 |
| Figure(s): | Fig.1, 2, 3, 4, 6, 7, 8 |
| Annotation description: | "To isolate axon-terminal D2 autoreceptor effects on DA release and uptake, we have used electrochemical recordings of evoked DA overflow in striatal slice preparations. Comparison of WT with D2-/- mice (Jung et al., 1999) revealed that the absence of D2 autoreceptor activity alters the kinetics of DA signaling via effects on both release and uptake." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Voltammetry assay |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | see also: "Dopamine D2 receptor-deficient mice exhibit decreased dopamine transporter function but no changes in dopamine release in dorsal striatum." @ PMID:9886065 |
| SynGO annotation ID: | 2543 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |