| Annotated protein: | Mineralocorticoid receptor (MR) (Nuclear receptor subfamily 3 group C member 2). Gene symbol: NR3C2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P22199 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NR3C2 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density, intracellular component (GO:0099092) |
| Synapse type(s): | amygdala, glutamatergic |
| Annotated paper: | Prager EM, et al. "Localization of mineralocorticoid receptors at mammalian synapses" PLoS One. 2010 Dec 15;5(12):e14344 PMID:21179518 |
| Figure(s): | Fig.6, 7 |
| Annotation description: | Fig.6: "GR and MR labeling at asymmetrical synapses" - "MR-ir and GR-ir was expressed in pre- and postsynaptic sites. Qualitative examination of asymmetrical synapses revealed both GR-ir and MR-ir (MA1-620 and rMR1-18 1D5) at the PSD (Fig. 6B-D) and MR-ir at the presynaptic terminal (Fig. 6D), compared to the primary antibody omitted PSD (Fig. 6A)." Fig.7: "Quantitative analysis of labeling at postsynaptic density of asymmetrical synapses" - "Planned contrasts between the groups revealed a significant difference between the primary antibody omitted control and both MRs and GR (t=10.496; p<.001)." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2545 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |