| Annotated protein: | Mineralocorticoid receptor (MR) (Nuclear receptor subfamily 3 group C member 2). Gene symbol: NR3C2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8VII8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NR3C2 |
| Ontology domain: | Biological Process |
| SynGO term: | presynaptic modulation of chemical synaptic transmission (GO:0099171) |
| Synapse type(s): | hippocampus, glutamatergic hippocampus, GABAergic |
| Annotated paper: | Olijslagers JE, et al. "Rapid changes in hippocampal CA1 pyramidal cell function via pre- as well as postsynaptic membrane mineralocorticoid receptors" Eur J Neurosci. 2008 May;27(10):2542-50 PMID:18547242 |
| Figure(s): | Table.1, Fig.3 |
| Annotation description: | Table.1: "Rapid effects of extracellularly or intracellularly administered corticosterone on hippocampal CA1 cell mEPSC and mIPSC parameters" - "Perfusion with the selective MR antagonist spironolactone (100 nm) by itself did not change mEPSC frequency compared to the baseline recording, but prevented the enhancement of mEPSC frequency induced by extracellularly applied corticosterone (Table 1)." Fig.3: "Retrograde signalling via CB1 receptors or nitric oxide is not involved in the effect of corticosterone on mEPSC frequency" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2548 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |