Annotated protein:	14-3-3 protein epsilon (14-3-3E) (Mitochondrial import stimulation factor L subunit) (MSF L). Gene symbol: YWHAE. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P62260
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SynGO gene info:	SynGO data @ YWHAE
Ontology domain:	Biological Process
SynGO term:	regulation of postsynaptic membrane neurotransmitter receptor levels (GO:0099072)
Synapse type(s):	cerebellum, glutamatergic
Annotated paper:	Chen BS, et al. "Growth factor-dependent trafficking of cerebellar NMDA receptors via protein kinase B/Akt phosphorylation of NR2C" Neuron. 2009 May 28;62(4):471-8 PMID:19477150
Figure(s):	fig 1, fig 4
Annotation description:	From Results section: "Consistent with the results from yeast two-hybrid interaction assay, we found that NR2C, but not NR2A and NR2B, coimmunoprecipitated with 14-3-33ε (Figure 1D), demonstrating that NR2C is a specific binding partner for 14-3-33ε in vivo." "Surface expression of NR2C WT was dramatically decreased upon cotransfection with 14-3-33ε dn (Figure 4), indicating that the interaction between NR2C and 14-3-3ε is required for NR2C trafficking. In addition, surface expression of NR2C S1096A was much less than that of NR2C WT when 14-3-33ε was coexpressed and was further reduced upon coexpression with 14-3-33ε dn (Figure 4), suggesting that S1096 is not the sole molecular determinant in 14-3-33-regulated NR2C trafficking."
Evidence tracking, Biological System:	Cultured neurons
Evidence tracking, Protein Targeting:	Antagonist / agonist Antibody (detection)
Evidence tracking, Experiment Assay:	Confocal IP + WB/MSMS
Annotator(s):	Rita Reig-Viader (ORCID:0000-0002-6893-6177) Àlex Bayés (ORCID:0000-0002-5265-6306)
Lab:	Molecular Physiology of the Synapse Laboratory, Biomedical Research Institute Sant Pau, 08025 Barcelona, Spain and and Universitat Autnoma de Cerdanyola del Valls, Spain Barcelona, 08193 Bellaterra
SynGO annotation ID:	2552
Dataset release (version):	20231201
View annotation as GO-CAM model: