| Annotated protein: | Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61). Gene symbol: ITGB3. Taxonomy: Homo sapiens (Human). Uniprot ID: P05106 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ITGB3 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic neurotransmitter receptor endocytosis (GO:0099149) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Cingolani LA, et al. "Activity-dependent regulation of synaptic AMPA receptor composition and abundance by beta3 integrins" Neuron. 2008 Jun 12;58(5):749-62 PMID:18549786 |
| Figure(s): | Fig 1, 3, 5, 6 |
| Annotation description: | ITGB3 Suppresses GluR2 Endocytosis. Postsynaptic ITGB3 Affects AMPAR Subunit Composition. 21/2/2018 Pim Fig.1: "RGD Peptides Reduce mEPSC Amplitude" Fig.3: "Integrins Regulate GluR2 Endocytosis" Fig.5: "Postsynaptic Expression of β3 Integrins Alters mEPSC Amplitude" Fig.6: "Postsynaptic β3 Integrins Affect AMPAR Subunit Composition" |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2603 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |