| Annotated protein: | Leucine-rich repeat and fibronectin type-III domain-containing protein 2. Gene symbol: LRFN2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q80TG9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ LRFN2 |
| Ontology domain: | Biological Process |
| SynGO term: | modulation of chemical synaptic transmission (GO:0050804) |
| Synapse type(s): | hippocampus Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Morimura N, et al. "Autism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice" Nat Commun. 2017 Jun 12;8:15800 PMID:28604739 |
| Figure(s): | fig 6 |
| Annotation description: | Enhanced LTP and reduction of the AMPAR/NMDAR ratio in the hippocampal Shaffer collateral-CA1 synapse pathway in LRFN2 KO mice. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp Field recordings |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2640 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |