| Annotated protein: | Neuronal cell adhesion molecule (Nr-CAM) (Neuronal surface protein Bravo) (mBravo) (NgCAM-related cell adhesion molecule) (Ng-CAM-related). Gene symbol: NRCAM. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q810U4 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NRCAM |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | brain, glutamatergic cerebral cortex, glutamatergic |
| Annotated paper: | Demyanenko GP, et al. "Neural cell adhesion molecule NrCAM regulates Semaphorin 3F-induced dendritic spine remodeling" J Neurosci. 2014 Aug 20;34(34):11274-87 PMID:25143608 |
| Figure(s): | fig 1 |
| Annotation description: | Immunostaining for NRCAM showed discrete localization on spine heads of EGFP-labeled, star pyramidal neurons in layer. Punctate immunofluorescent staining of NRCAM on dendritic spines in V1, layer 4 of WT mice. Punctate immunofluorescent colocalization of NRCAM with MAP2 at dendritic spines in V1 at P21 in coronal sections. Fractionation of P21 mouse brain showed that NRCAM distributed within PSD fraction (PSD-2T) identified by enrichment in postsynaptic markers, NMDA receptor NR1 subunit, and PSD-95. 2/3/2019 Pim - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Western blot Biochemical fractionation (generic) |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2643 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |