| Annotated protein: | Neuronal cell adhesion molecule (Nr-CAM) (Neuronal surface protein Bravo) (mBravo) (NgCAM-related cell adhesion molecule) (Ng-CAM-related). Gene symbol: NRCAM. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q810U4 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NRCAM |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynapse organization (GO:0099175) |
| Synapse type(s): | cerebral cortex, glutamatergic |
| Annotated paper: | Demyanenko GP, et al. "Neural cell adhesion molecule NrCAM regulates Semaphorin 3F-induced dendritic spine remodeling" J Neurosci. 2014 Aug 20;34(34):11274-87 PMID:25143608 |
| Figure(s): | fig 2, 3, 4, 6, 7 |
| Annotation description: | NRCAM regulates dendritic spine density on pyramidal neurons in mouse visual cortex. NRCAM deficiency increases excitatory spine synapses and neurotransmission in layer 4 of visual cortex. NRCAM mice have higher rates of spontaneous mEPSCs. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal Whole-cell patch clamp |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2644 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |