| Annotated protein: | VPS10 domain-containing receptor SorCS3. Gene symbol: SORCS3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8VI51 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SORCS3 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic modulation of chemical synaptic transmission (GO:0099170) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Breiderhoff T, et al. "Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction" PLoS One. 2013 Sep 19;8(9):e75006 PMID:24069373 |
| Figure(s): | Fig.4, 9 |
| Annotation description: | Figure 4: "Long-term depression is impaired in SORCS3-deficient mice" - "the synaptic activation of NMDA receptors triggers the induction of LTD [19,21]. As shown in Figure 4A and B, NMDA receptor-dependent-LTD was absent in hippocampal slices from Sorcs3-/- animals. Another form of LTD is mGluR-dependent whereby synaptic activation of metabotropic glutamate receptors triggers LTD [19,22]. Remarkably, mGluR-dependent LTD was also lost in SORCS3-deficient mice (Figure 4C and D)." Fig.9: "SORCS3 interacts with PICK1 and affects its localization at the postsynaptic density" Note: PICK1 is a protein known to be involved in AMPAR internalization. The overall modal is that SORCS3 is present in the postsynapse and via an unknown mechanism modulates AMPAR internalization. Beacuse the mechanism is unclear I have used the general term 'postsynaptic modulation of chemical synaptic transmission (GO:0099170)'. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Antibody (detection) |
| Evidence tracking, Experiment Assay: | Field recordings Western blot Biochemical fractionation (generic) |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2666 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |