| Annotated protein: | Leucine-rich repeat-containing protein 4C (Netrin-G1 ligand) (NGL-1). Gene symbol: LRRC4C. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8C031 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ LRRC4C |
| Ontology domain: | Biological Process |
| SynGO term: | synapse adhesion between pre- and post-synapse (GO:0099560) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Matsukawa H, et al. "Netrin-G/NGL complexes encode functional synaptic diversification" J Neurosci. 2014 Nov 19;34(47):15779-92 PMID:25411505 |
| Figure(s): | Fig 1, Fig 6E, 7, 8 |
| Annotation description: | LRRC4C KO mice showed impaired post-tetanic depression (PTD) in hippocampus MPP-DG pathway. 21/2/2018 Pim Fig.7: "Disappearance of presynaptic netrin-Gs in NGL-KO mice" Fig.8: "Synaptic localization and surface expression levels of netrin-Gs regulated by postsynaptic NGLs. " - "... total amounts of P2-netrin-G1 were decreased in NGL1-KO mice (Fig. 8A). The reduction of SPM-netrin-G1 was more evident in NGL1-KO mice (Fig. 8B). Consistent with the biochemical data, immunohistochemical analysis revealed a markedly reduced intensity for netrin-G1 in NGL1-KO mice (Fig. 8C)." - LRRC4C is located at the postsynaptic membrane (Fig.1, see also ticket #2221) - Interacts with presynaptic netrin-G1 (Fig.1, see also ticket #2321) - PMID:14595443 shows the adhesive properties of LRRC4C and netrin-G1. - Conclusion is that pre/postsynaptic netrin-G1/LRRC4C modulate synaptic transmission via cell-cell-adhesion. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Field recordings Western blot Biochemical fractionation (generic) |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| Additional literature: | Specific and direct interaction of LRRC4C and netrin-G1 on the cell surface. Surface-bound LRRC4C may promote neurite outgrowth of developing thalamic neurons and that such activity may be at least partially dependent on GPI-anchored netrin-G1 present on the thalamic neurons. Contains evidence for cel-adhesion. @ PMID:14595443 |
| SynGO annotation ID: | 2678 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |