| Annotated protein: | Glutamate receptor ionotropic, delta-1 (GluD1) (GluR delta-1 subunit). Gene symbol: GRID1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q61627 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRID1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Hepp R, et al. "Glutamate receptors of the delta family are widely expressed in the adult brain" Brain Struct Funct. 2015 Sep;220(5):2797-815 PMID:25001082 |
| Figure(s): | Figure 8 |
| Annotation description: | GluD1 is shown to primarily localize to the postsynaptic density of excitatory synapses in CA1 neurons of the mouse hippocampus (Figure 8 g, h). Antibodies used for electron microscopy analyses were validated by western blotting using GRID1-/- and did not cross react with GluD2 in HEK cells (Figure 5a,b) |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Hana Goldschmidt (ORCID:0000-0002-5676-366X) Richard Huganir (ORCID:0000-0001-9783-5183) |
| Lab: | Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA and Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21205, USA |
| SynGO annotation ID: | 2693 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |