| Annotated protein: | Neuroligin-1 (Neuroligin I). Gene symbol: NLGN1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q62765 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NLGN1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic specialization membrane (GO:0099060) |
| Synapse type(s): | neocortex, glutamatergic |
| Annotated paper: | Song JY, et al. "Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses" Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):1100-5 PMID:9927700 |
| Figure(s): | Fig.4 |
| Annotation description: | Fig.4: "We observed a selective accumulation of immunogold particles in synaptic clefts and postsynaptic densities as a function of neuroligin staining (Fig. (Fig.44A). Only asymmetric synapses appeared to contain neuroligin 1. Typically, synapses were decorated with 2-6 gold particles in the synaptic cleft and/or adjacent postsynaptic densities. As our antibody was raised against the extracellular domain of neuroligin 1, the presence of gold particles in the synaptic cleft indicates that neuroligin 1 extends into the synaptic cleft. The clustering of gold particles in the postsynaptic density suggests that neuroligin 1 is (on average) closer to the postsynaptic side of the synapse." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | NLGN1; neuroligin 1 binds PSD-95 @ PMID:9278515 |
| SynGO annotation ID: | 2744 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |