Annotated protein:Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha). Gene symbol: NRXN1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q63372
antibody wiki:
SynGO gene info:SynGO data @ NRXN1
Ontology domain:Biological Process
SynGO term:presynapse assembly (GO:0099054)
Synapse type(s):hippocampus
Annotated paper:Dean C, et al. "Neurexin mediates the assembly of presynaptic terminals" Nat Neurosci. 2003 Jul;6(7):708-16 PMID:12796785
Figure(s):Fig.5, 6, 7
Annotation description:Rationale: NLGN1; neuroligin 1 is a postsynaptic protein. Neurexin-1beta is a presynaptic protein (Fig.4, 6, 7). These proteins are shown to mediate cell-cell adhesion (Fig.2). Together this means that these proteins are involved in 'synapse adhesion between pre- and post-synapse (GO:0099560)'. The relevance of this interaction is shown in the ability of these two protein to be able to induce pre- and postsynaptic differentiation (Fig.6, 7 and ticket #2745).

Fig.5: "Overexpression of neuroligin-1 induces recruitment of neurexin to newly forming synapses"
Fig.6: "Induction of neurexin clustering and presynaptic differentiation by purified neuroligin"
Fig.7: "Clustering of neurexin is sufficient to induce recruitment of synaptic vesicles"
Evidence tracking, Biological System:Cultured neurons
Evidence tracking, Protein Targeting:Over-expression
Antagonist / agonist
Antibody (detection)
Evidence tracking, Experiment Assay:Confocal
Annotator(s):Pim van Nierop (ORCID:0000-0003-0593-3443)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:2748
Dataset release (version):20210225
View annotation as GO-CAM model:Gene Ontology