Annotated protein:	Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha). Gene symbol: NRXN1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9CS84
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SynGO gene info:	SynGO data @ NRXN1
Ontology domain:	Cellular Component
SynGO term:	integral component of presynaptic active zone membrane (GO:0099059)
Synapse type(s):	neocortex, glutamatergic hippocampus, glutamatergic
Annotated paper:	Taniguchi H, et al. "Silencing of neuroligin function by postsynaptic neurexins" J Neurosci. 2007 Mar 14;27(11):2815-24 PMID:17360903
Figure(s):	Fig.2
Annotation description:	Note: Fig.1 shows pre- and postsynaptic localization of Nrxn1; neurexin 1 beta, but uses a pan-neurexin antibody that does not distinguish neurexin paralogs. Fig.2: "As observed with the pan-neurexin antibodies, also the tagged NRX1β4(+) protein was detected in axons (Fig. 2D) and dendrites (Fig. 2E). At the cell surface, we observed strongest immunoreactivity at the plasma membrane of axons (51 ± 4 and 55 ± 6% of particles in cortex and hippocampal formation, respectively), followed by the plasma membrane of dendrites (11 ± 2 and 17 ± 3%, respectively) (Table 1). At some synapses, prominent labeling was observed in presynaptic or postsynaptic compartments, directly at the active zone and postsynaptic density (Fig. 2E)" - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen.
Evidence tracking, Biological System:	Intact tissue
Evidence tracking, Protein Targeting:	Over-expression
Evidence tracking, Experiment Assay:	Electron Microscopy
Annotator(s):	Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:	Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:	2750
Dataset release (version):	20231201
View annotation as GO-CAM model: