| Annotated protein: | Neuroligin-2. Gene symbol: NLGN2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q69ZK9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NLGN2 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic specialization membrane (GO:0099060) |
| Synapse type(s): | striatum, dopaminergic |
| Annotated paper: | Uchigashima M, et al. "Dopamine synapse is a neuroligin-2-mediated contact between dopaminergic presynaptic and GABAergic postsynaptic structures" Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):4206-11 PMID:27035941 |
| Figure(s): | Fig.3, S3 |
| Annotation description: | Note: NLGN-2: Neuroligin 2 is classically known to be located in the postsynaptic speciallization of GABAergic synapses. This publication shows that the postsynapse of dopaminergic synapses has a GABAergic signature, including NLGN-2: Neuroligin 2 presence. Fig.3: "GABAergic postsynaptic phenotype at striatal dopamine synapses" Fig.S3: "Expression of GABAergic, but not glutamatergic, postsynaptic proteins at dopamine synapses" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2752 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |