| Annotated protein: | Neuroligin-2. Gene symbol: NLGN2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q69ZK9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NLGN2 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic specialization assembly (GO:0098698) |
| Synapse type(s): | hippocampus, GABAergic brainstem, GABAergic brainstem, glycinergic |
| Annotated paper: | Poulopoulos A, et al. "Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin" Neuron. 2009 Sep 10;63(5):628-42 PMID:19755106 |
| Figure(s): | Fig.1, 2, 4, 5, 6 |
| Annotation description: | Fig.1: "Neuroligins Interact with Gephyrin" Fig.2: "The Interaction of NL2 with Gephyrin Promotes Coclustering in Neurons" Fig.4: "NL2 Is Required for Proper GABAergic and Glycinergic but Not Glutamatergic Transmission in the Brainstem" Fig.5: "NL2-/- Neurons in Culture Display Deficits in Postsynaptic Targeting of Gephyrin at Perisomatic Synapses" Fig.6: "GABAergic Transmission and Postsynaptic Differentiation Are Perturbed at Perisomatic Synapses in the Hippocampus of NL2-/- Mice" |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp IP + WB/MSMS Y2H |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2754 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |