Annotated protein:Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha). Gene symbol: NRXN1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9CS84
antibody wiki:
SynGO gene info:SynGO data @ NRXN1
Ontology domain:Biological Process
SynGO term:regulation of postsynaptic specialization assembly (GO:0099150)
Synapse type(s):hippocampus, glutamatergic
hippocampus, GABAergic
Annotated paper:Graf ER, et al. "Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins" Cell. 2004 Dec 29;119(7):1013-26 PMID:15620359
Figure(s):Fig.2, 3, 4
Annotation description:Fig.2: "Neurexin Clusters GABA and NMDA Glutamate Receptors"
Fig.3: "Neurexin Clusters Neuroligins but Not Dystroglycan"
Fig.4: "Purified Neurexin Coclusters Neuroligins with Postsynaptic Proteins"
Evidence tracking, Biological System:Cultured neurons
Non-neuronal tissue
Evidence tracking, Protein Targeting:Over-expression
Evidence tracking, Experiment Assay:Confocal
Annotator(s):Pim van Nierop (ORCID:0000-0003-0593-3443)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:2757
Dataset release (version):20210225
View annotation as GO-CAM model:Gene Ontology