| Annotated protein: | Neuroligin-1. Gene symbol: NLGN1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q99K10 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NLGN1 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic specialization assembly (GO:0098698) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Graf ER, et al. "Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins" Cell. 2004 Dec 29;119(7):1013-26 PMID:15620359 |
| Figure(s): | Fig.2, 3, 4, 5 |
| Annotation description: | Fig.2: "Neurexin Clusters GABA and NMDA Glutamate Receptors" Fig.3: "Neurexin Clusters Neuroligins but Not Dystroglycan" Fig.4: "Purified Neurexin Coclusters Neuroligins with Postsynaptic Proteins" Fig.5: "Neuroligin Aggregation Alone Is Synaptogenic" - "Transfection of neurons with low levels of YFP-neuroligin followed by application of beads bearing anti-YFP antibodies resulted in local clustering of the YFP-neuroligin on the surface of transfected dendrites. Such direct aggregation of YFP-neuroligin-1 resulted in coaggregation of PSD-95 but not gephyrin (Figure 5A)." |
| Evidence tracking, Biological System: | Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2758 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |