| Annotated protein: | Neuroligin-3 (Gliotactin homolog). Gene symbol: NLGN3. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q62889 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NLGN3 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic specialization assembly (GO:0098698) |
| Synapse type(s): | hippocampus, GABAergic hippocampus, glutamatergic |
| Annotated paper: | Budreck EC, et al. "Neuroligin-3 is a neuronal adhesion protein at GABAergic and glutamatergic synapses" Eur J Neurosci. 2007 Oct;26(7):1738-48 PMID:17897391 |
| Figure(s): | Fig.5 |
| Annotation description: | Fig.5: "Neurexin promotes coaggregation of NL3 with glutamatergic and GABAergic postsynaptic scaffolds." Note: this data is correlational in nature. The annotation relies on the known ability of neurexin-1 to induce clustering and postsynaptic differentiation via neuroligins. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2769 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |