| Annotated protein: | Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR 2) (CNK homolog protein 2) (CNK2) (Membrane-associated guanylate kinase-interacting protein) (Maguin). Gene symbol: CNKSR2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9Z1T4 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CNKSR2 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynapse organization (GO:0099173) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Lim J, et al. "The CNK2 scaffold interacts with vilse and modulates Rac cycling during spine morphogenesis in hippocampal neurons" Curr Biol. 2014 Mar 31;24(7):786-92 PMID:24656827 |
| Figure(s): | Fig.3, 4 |
| Annotation description: | Fig.3: "CNK2 is Required for Dendritic Spine Morphogenesis" Fig.4: "CNK2 Modulates RacGDP/GTP Cycling During Spine Morphogenesis" |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2788 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |