| Annotated protein: | FERM and PDZ domain containing 4. Gene symbol: FRMPD4. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: D4A3K7 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ FRMPD4 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic actin cytoskeleton organization (GO:0098974) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Lee HW, et al. "Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis" J Neurosci. 2008 Dec 31;28(53):14546-56 PMID:19118189 |
| Figure(s): | Fig.4, 5, 6, 7, 8 |
| Annotation description: | Fig.4: "Dendritic spine density is regulated by Preso overexpression and dominant-negative inhibition" Fig.5: "Preso knockdown decreases the number of dendritic spines and excitatory synapses" Fig.6: "Preso knockdown decreases excitatory synaptic transmission" Fig.7: "Preso interacts with βPix and increases spine density in a manner requiring the PDZ and FERM domains" - Note: betaPix is a known regulator of actin dynamics in the synapse Fig.8: "Knockdown or inhibition of Preso reduces F-actin levels in dendritic spines" |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp IP + WB/MSMS |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2820 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |