| Annotated protein: | Regulator of G-protein signaling 14 (RGS14) (RAP1/RAP2-interacting protein) (RPIP1). Gene symbol: RGS14. Taxonomy: Mus musculus (Mouse). Uniprot ID: P97492 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RGS14 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Lee SE, et al. "RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory" Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16994-8 PMID:20837545 |
| Figure(s): | Fig.1 |
| Annotation description: | Fig.1: "RGS14 is enriched in hippocampal CA2 neurons" - "At the electron microscopic (EM) level, RGS14 labeling in CA2 hippocampal neurons is predominantly found in dendritic shafts (Fig. 1G), as well as necks or heads of dendritic spines (Fig. 1 H and I), including an apparent enrichment at some postsynaptic densities (PSD) (Fig. 1I)." See also: pmd:29518331 |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2865 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |